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Towards malaria elimination

The launch of a new thematic series of Malaria Journal, "Towards malaria elimination", creates the forum that allows carrying scientific evidence on how to achieve malaria elimination in specific endemic settings and conditions into the circles of scientists, public health specialists, national and global programme managers, funders and decision makers.

"Towards malaria elimination" welcomes original papers, reviews, commentaries and opinion pieces on malaria elimination and eradication, and hopes that this mix of scientific information and debate will catalyze and dynamize the move towards more intensified control and progressively malaria elimination within a spirit of mutual learning for change. The Editors very much hope that many scientists, public health professionals and policy makers will start using "Towards malaria elimination" as one of their ways to share new evidence or to discuss evidence presented in the scientific literature.

View all collections published in Malaria Journal.

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  1. The emergence of Plasmodium falciparum drug resistance against artemisinin-based combination therapy has threatened malaria control efforts. Since malaria control and elimination plans are dependent on these drug...

    Authors: Dagmawi Woldesenbet, Meseret Birhanie, Aberham Abere, Ayalew Jejaw Zeleke, Migbaru Keffale Bezabih, Muluken Semaw, Menberu Wubetie, Wagaw Abebe, Elias Tamene and Yalewayker Tegegne
    Citation: Malaria Journal 2024 23:266
    Content type: Research Published on:

  3. Nigeria has the highest malaria burden globally, and anti-malarials have been commonly used to treat malaria without parasitological confirmation. In 2012, Nigeria implemented rapid diagnostic tests (RDTs) to ...

    Authors: Sandra C. Olisakwe, Julie Thwing, Jodie A. Dionne, Ryan Irvin, Patrick S. Kachur and Katia J. Bruxvoort
    Citation: Malaria Journal 2024 23:249
    Content type: Research Published on:

  4. Ghana is a malaria-endemic country with the entire population at risk. The Northern region of the country recorded the highest malaria case fatality rate (CFR) for two consecutive years: 1.11% in 2013 and 1.07...

    Authors: Nana Yaw Peprah, Wahjib Mohammed, George Asumah Adu, Dora Dadzie, Sammy Oppong, Seidu Barikisu, Joel Narh, Stephen Appiah, James Frimpong and Keziah L. Malm
    Citation: Malaria Journal 2024 23:230
    Content type: Research Published on:

  5. Biological control is a promising alternative or complementary approach for controlling vector populations in response to the spread of insecticide resistance in malaria vectors. This study evaluated the effic...

    Authors: Herieth H. Mahenge, Letus L. Muyaga, Joel D. Nkya, Andrew D. Kafwenji, Yohana A. Mwalugelo, Najat F. Kahamba, Halfan S. Ngowo and Emmanuel W. Kaindoa
    Citation: Malaria Journal 2024 23:228
    Content type: Research Published on:

  6. Thailand aimed to eliminate malaria by 2024, and as such is planning for future prevention of re-establishment in malaria free provinces. Understanding the receptivity of local areas to malaria allows the appr...

    Authors: Rebecca Walshe, Kulchada Pongsoipetch, Suwanna Mukem, Tanong Kamsri, Navarat Singkham, Prayuth Sudathip, Suravadee Kitchakarn, Rapeephan Rattanawongnara Maude and Richard James Maude
    Citation: Malaria Journal 2024 23:224
    Content type: Research Published on:

  7. Malaria remains a global health challenge, particularly in Peru's Loreto region. Despite ongoing efforts, high infection rates and asymptomatic cases perpetuate transmission. The Peruvian Ministry of Health’s ...

    Authors: Viviana Pinedo-Cancino, Katty M. Arista, G. Christian Baldeviano, Rafael Saavedra-Langer, Andrei Arana, Maria E. Vásquez-Chasnamote, Andree Valle-Campos, Juan C. Castro, Julio A. Ventocilla, Edward S. Smith, Andres G. Lescano and Lastenia Ruíz-Mesia
    Citation: Malaria Journal 2024 23:209
    Content type: Research Published on:

  8. While substantial gains have been made in the fight against malaria over the past 20 years, malaria morbidity and mortality are marked by inequality. The equitable elimination of malaria within countries will ...

    Authors: Angela E. Apeagyei, Nishali K. Patel, Ian Cogswell, Kevin O’Rourke, Golsum Tsakalos and Joseph Dieleman
    Citation: Malaria Journal 2024 23:206
    Content type: Research Published on:

    The Publisher Correction to this article has been published in Malaria Journal 2024 23:248

  9. Malaria remains a severe parasitic disease, posing a significant threat to public health and hindering economic development in sub-Saharan Africa. Ethiopia, a malaria endemic country, is facing a resurgence of...

    Authors: Beka R. Abagero, Rei Rama, Abdulghani Obeid, Tirusew Tolosa, Biniyam Lukas, Taye Teka, Daniel Tesfaye, Eugenia Lo and Delenasaw Yewhalaw
    Citation: Malaria Journal 2024 23:194
    Content type: Research Published on:

  11. With only one 15 mg primaquine tablet registered by a stringent regulatory authority and marketed, more quality-assured primaquine is needed to meet the demands of malaria elimination.

    Authors: Julie Nguyen Ngoc Pouplin, Thoopmanee Kaendiao, Bilal Ahmad Rahimi, Mayur Soni, Hensi Basopia, Darshana Shah, Jitendra Patil, Vyom Dholakia, Yash Suthar, Joel Tarning, Mavuto Mukaka and Walter R. Taylor
    Citation: Malaria Journal 2024 23:176
    Content type: Research Published on:

  12. National Malaria Programmes (NMPs) monitor the durability of insecticide-treated nets (ITNs) to inform procurement and replacement decisions. This is crucial for new dual active ingredients (AI) ITNs, for whic...

    Authors: Jacky Raharinjatovo, Roch Kounbobr Dabiré, Keith Esch, Dieudonné Diloma Soma, Aristide Hien, Tiecoura Camara, Mame Birame Diouf, Allison Belemvire, Lilia Gerberg, Taiwo Samson Awolola, Adama Koné, Djenam Jacob, Sophie Vandecandelaere, Marie Baes and Stephen Poyer
    Citation: Malaria Journal 2024 23:173
    Content type: Research Published on:

  13. Mexico has experienced a significant reduction in malaria cases over the past two decades. Certification of localities as malaria-free areas (MFAs) has been proposed as a steppingstone before elimination is ac...

    Authors: Denis Escobar, Gabriela González-Olvera, Ángel S. Gómez-Rivera, Juan Navarrete-Carballo, Pedro Mis-Ávila, Raquel Baack-Valle, Guillermo Escalante, Gerardo Reyes-Cabrera, Fabian Correa-Morales, Azael Che-Mendoza, Gonzalo Vazquez-Prokopec, Audrey Lenhart and Pablo Manrique-Saide
    Citation: Malaria Journal 2024 23:165
    Content type: Research Published on:

  14. Malaria is a major public health concern in Ethiopia, where more than half of the population lives in malaria risk areas. While several studies have been conducted in different eco-epidemiological settings in ...

    Authors: Kinfu Boresa, Tariku Belay, Abdissa Biruksew, Eshetu Alemayehu and Endalew Zemene
    Citation: Malaria Journal 2024 23:152
    Content type: Research Published on:

  15. Despite continuous prevention and control strategies in place, malaria remains a major public health problem in sub-Saharan Africa including Ethiopia. Moreover, prevalence of malaria differs in different geogr...

    Authors: Girma Yutura, Fekadu Massebo, Nigatu Eligo, Abena Kochora and Teklu Wegayehu
    Citation: Malaria Journal 2024 23:143
    Content type: Research Published on:

  16. In 2021 and 2023, the World Health Organization approved RTS,S/AS01 and R21/Matrix M malaria vaccines, respectively, for routine immunization of children in African countries with moderate to high transmission...

    Authors: Beatus M. Lyimo, Catherine Bakari, Zachary R. Popkin-Hall, David J. Giesbrecht, Misago D. Seth, Dativa Pereus, Zulfa I. Shabani, Ramadhan Moshi, Ruth Boniface, Celine I. Mandara, Rashid Madebe, Jonathan J. Juliano, Jeffrey A. Bailey and Deus S. Ishengoma
    Citation: Malaria Journal 2024 23:139
    Content type: Research Published on:

  18. There are giant steps taken in the introduction of the novel malaria vaccine poised towards reducing mortality and morbidity associated with malaria.

    Authors: Awoere T. Chinawa, Edmund N. Ossai, Vivian O. Onukwuli, Obinna C. Nduagubam, Ndubuisi A. Uwaezuoke, Chinyere N. Okafor and Josephat M. Chinawa
    Citation: Malaria Journal 2024 23:117
    Content type: Research Published on:

  19. Rapid diagnostic tests (RDTs) play a significant role in expanding case management in peripheral healthcare systems. Histidine-rich protein-2 (HRP2) antigen detection RDTs are predominantly used to diagnose Plasm...

    Authors: Bacha Mekonen, Sisay Dugassa, Sindew Mekasha Feleke, Boja Dufera, Bedasa Gidisa, Aderaw Adamu, Aynalem Mandefro, Geremew Tasew and Lemu Golassa
    Citation: Malaria Journal 2024 23:108
    Content type: Research Published on:

  20. In sub-Saharan Africa (SSA), Plasmodium falciparum causes most of the malaria cases. Despite its crucial roles in disease severity and drug resistance, comprehensive data on Plasmodium falciparum genetic diversit...

    Authors: Alex Mwesigwa, Moses Ocan, Benson Musinguzi, Rachel Wangi Nante, Joaniter I. Nankabirwa, Steven M. Kiwuwa, Alison Annet Kinengyere, Barbara Castelnuovo, Charles Karamagi, Ekwaro A. Obuku, Samuel L. Nsobya, Sam M. Mbulaiteye and Pauline Byakika-Kibwika
    Citation: Malaria Journal 2024 23:97
    Content type: Review Published on:

  21. Malaria remains a public health problem in regions of Northeastern India because of favourable bio-geographic transmission conditions, poor access to routine healthcare, and inadequate infrastructure for publi...

    Authors: Carinthia B. Nengnong, Mattimi Passah, Mark L. Wilson, Elisa Bellotti, Anne Kessler, Bibha R. Marak, Jane M. Carlton, Rajiv Sarkar and Sandra Albert
    Citation: Malaria Journal 2024 23:83
    Content type: Research Published on:

  22. Vegetation health (VH) is a powerful characteristic for forecasting malaria incidence in regions where the disease is prevalent. This study aims to determine how vegetation health affects the prevalence of mal...

    Authors: Gouvidé Jean Gbaguidi, Mouhamed Idrissou, Nikita Topanou, Walter Leal Filho and Guillaume K. Ketoh
    Citation: Malaria Journal 2024 23:78
    Content type: Research Published on:

  23. Pyrethroid-based indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) have been employed as key vector control measures against malaria in Namibia. However, pyrethroid resistance in Anopheles

    Authors: Rosalia N. Joseph, Tabeth Mwema, Seth J. Eiseb, Deodatus V. Maliti, Munyaradzi Tambo, Iitula Iitula, Lydia Eloff, Ophilia Lukubwe, Cara Smith-Gueye, Élodie A. Vajda, Allison Tatarsky, Stark T. Katokele, Petrina N. Uusiku, Dennis Walusimbi, Sheila B. Ogoma, Davis R. Mumbengegwi…
    Citation: Malaria Journal 2024 23:77
    Content type: Research Published on:

  24. Genetic surveillance of the Plasmodium falciparum parasite shows great promise for helping National Malaria Control Programmes (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polyge...

    Authors: Wesley Wong, Stephen F. Schaffner, Julie Thwing, Mame Cheikh Seck, Jules Gomis, Younouss Diedhiou, Ngayo Sy, Medoune Ndiop, Fatou Ba, Ibrahima Diallo, Doudou Sene, Mamadou Alpha Diallo, Yaye Die Ndiaye, Mouhamad Sy, Aita Sene, Djiby Sow…
    Citation: Malaria Journal 2024 23:68
    Content type: Research Published on:

  25. The malaria incidence data from a malaria prevention study from the Rift Valley, Central Ethiopia, were reanalysed. The objective was to investigate whether including an administrative structure within the soc...

    Authors: Taye Gari and Bernt Lindtjørn
    Citation: Malaria Journal 2024 23:67
    Content type: Research Published on:

  26. Malaria elimination requires closely co-ordinated action between neighbouring countries. In Southern Africa several countries have reduced malaria to low levels, but the goal of elimination has eluded them thu...

    Authors: Chadwick H. Sikaala, Bongani Dlamini, Alphart Lungu, Phelele Fakudze, Mukosha Chisenga, Chishala Lukwesa Siame, Nyasha Mwendera, Dumisani Shaba, John M. Chimumbwa and Immo Kleinschmidt
    Citation: Malaria Journal 2024 23:62
    Content type: Case Study Published on:

    The Correction to this article has been published in Malaria Journal 2024 23:98

  27. By 2022, the Government of Indonesia had successfully eliminated malaria in 389 out of 514 districts but continues to face a challenge in Eastern Indonesia where 95% of the total 2021 malaria cases were report...

    Authors: Dee Jupp, Sherria Ayuandini, Frisca Tobing, Denny Halim, Enny Kenangalem, Maria E. Sumiwi, Hellen D. Prameswari, Minerva Theodora, Hermawan Susanto, Riskha T. P. Dewi, Dedy Supriyanto, Bayu Kurnia, Mrunal Shetye, Ermi Ndoen and Yuka Onishi
    Citation: Malaria Journal 2024 23:59
    Content type: Research Published on:

  28. Gabon still bears significant malaria burden despite numerous efforts. To reduce this burden, policy-makers need strategies to design effective interventions. Besides, malaria distribution is well known to be ...

    Authors: Fabrice Mougeni, Bertrand Lell, Ngianga-Bakwin Kandala and Tobias Chirwa
    Citation: Malaria Journal 2024 23:57
    Content type: Research Published on:

  29. Mass Drug Administration (MDA) has become a mainstay for the control of several diseases over the last two decades. Successful implementation of MDA programmes requires community participation and can be threa...

    Authors: Christian Kositz, Hristina Vasileva, Nuredin Mohammed, Jane Achan, Edgard Diniba Dabira, Umberto D’Alessandro, John Bradley and Michael Marks
    Citation: Malaria Journal 2024 23:54
    Content type: Research Published on:

  31. Malaria remains an enduring public health concern in Indonesia, exacerbated by its equatorial climate that fosters the proliferation of Anopheles mosquitoes. This study seeks to assess the performance of the mala...

    Authors: Hamzah Hasyim, Heni Marini, Misnaniarti Misnaniarti, Rostika Flora, Iche Andriyani Liberty, Ahmed Elagali, Hartoni Hartoni and Fadhilah Eka Maharani
    Citation: Malaria Journal 2024 23:43
    Content type: Research Published on:

  32. The emergence of insecticide resistance and outdoor transmission in malaria-endemic areas underlines the urgent need to develop innovative tools, such as spatial repellents (SR), that may circumvent this resid...

    Authors: Lepa Syahrani, Puji B. S. Asih, Anom Bowolaksono, Astari Dwiranti, Siti Zubaidah, Ismail E. Rozi, Dendi H. Permana, Claus Bøgh, Michael J. Bangs, John P. Grieco, Nicole L. Achee, Neil F. Lobo and Din Syafruddin
    Citation: Malaria Journal 2024 23:31
    Content type: Research Published on:

  33. Malaria remains a significant public health concern in Niger, with the number of cases increasing from 592,334 in 2000 to 3,138,696 in 2010. In response, a concerted campaign against the disease has been initi...

    Authors: Ali Issakou Malam Tchole, Run-Ze Ye, Qing Xu, Zhen-Wei Li, Jin-Yue Liu, Shan-Shan Wang, Jing Liu, Xiao-Yang Wang, Alassan Maman Bachir, Lin Zhao and Wu-Chun Cao
    Citation: Malaria Journal 2024 23:30
    Content type: Research Published on:

  34. Malaria outbreaks are detected by applying the World Health Organization (WHO)-recommended thresholds (the less sensitive 75th percentile or mean + 2 standard deviations [2SD] for medium-to high-transmission a...

    Authors: Marie Gorreti Zalwango, Jane F. Zalwango, Daniel Kadobera, Lilian Bulage, Carol Nanziri, Richard Migisha, Bosco B. Agaba, Benon Kwesiga, Jimmy Opigo, Alex Riolexus Ario and Julie R. Harris
    Citation: Malaria Journal 2024 23:18
    Content type: Research Published on:

  35. Approximately 32 million pregnant women are at risk of malaria with up to 10,000 maternal deaths and 200,000 neonates at risk annually. Intermittent Preventive Treatment (IPT) with sulfadoxine-pyrimethamine (S...

    Authors: Sabrina Lynda Simo Kamga, Innocent Mbulli Ali, Ghislain Romeo Ngangnang, Mehmet Can Ulucesme, Leonard T. D. Keptcheu, Eva Mai Keming, Valery-Pacome Kom Tchuenkam, Juluis Visnel Foyet, Münir Aktas, Michel Noubom and Vincent K. Payne
    Citation: Malaria Journal 2024 23:6
    Content type: Research Published on:

  36. Malaria is still endemic in South Korea. However, limited information is available on the current Anopheles breeding sites and the occurrence of insecticide resistance-associated genetic mutations and their distr...

    Authors: Hyelee Hong, Tae-Hui Eom, Thuy-Tien Thi Trinh, Bao Duong Tuan, Hyun Park and Seon-Ju Yeo
    Citation: Malaria Journal 2023 22:381
    Content type: Research Published on:

  37. Mass drug administration (MDA) and indoor residual spraying (IRS) are potent malaria burden reduction tools. The impact of combining MDA and IRS is not well documented. We evaluated the impact of MDA + IRS com...

    Authors: Mulebeke Ronald, Wanzira Humphrey, Yeka Adoke and Van Geertruyden Jean-Pierre
    Citation: Malaria Journal 2023 22:378
    Content type: Research Published on:

  38. Plasmodium falciparum genetic diversity can add information on transmission intensity and can be used to track control and elimination interventions.

    Authors: Abeba Gebretsadik Reda, Tiffany Huwe, Cristian Koepfli, Ashenafi Assefa, Sofonias Kifle Tessema, Alebachew Messele, Lemu Golassa and Hassen Mamo
    Citation: Malaria Journal 2023 22:376
    Content type: Research Published on:

  39. In 2020, the Zambia National Malaria Elimination Centre targeted the distribution of long-lasting insecticidal nets (LLINs) and indoor-residual spraying (IRS) campaigns based on sub-district micro-planning, wh...

    Authors: Irene Kyomuhangi, Andrew Andrada, Zhiyuan Mao, Derek Pollard, Christina Riley, Adam Bennett, Busiku Hamainza, Hannah Slater, Justin Millar, John M. Miller, Thomas P. Eisele and Kafula Silumbe
    Citation: Malaria Journal 2023 22:365
    Content type: Research Published on:

  40. Dual hrp2/hrp3 genes deletions in P. falciparum isolates are increasingly reported in malaria-endemic countries and can produce false negative RDT results leading to inadequate case management. Data on the freque...

    Authors: Casimire Wendlamita Tarama, Harouna Soré, Mafama Siribié, Siaka Débé, Réné Kinda, Wendyam Gérard Nonkani, Farida Tiendrebeogo, Winnie Bantango, Kassoum Yira, Esther Yéri Hien, Moussa Wandaogo Guelbéogo, Yves Traoré, Didier Ménard and Adama Gansané
    Citation: Malaria Journal 2023 22:363
    Content type: Research Published on:

  41. Plasmodium vivax is the main species responsible for human malaria in Brazil, and one of its manifestations is splenic malaria, though there are still challenges in its diagnosis. The present study aimed to stand...

    Authors: Raimunda Sandra Pacheco Souza, Monique F. dos Reis, Luiz Carlos de Lima Ferreira, Manuela C. Morais, Antonio Kassio S. Lima, Laila Rowena Albuquerque Barbosa, Gisely Cardoso de Melo and Marcus Vinicius Guimaraes de Lacerda
    Citation: Malaria Journal 2023 22:361
    Content type: Research Published on:

  42. Karnataka is one of the largest states in India and has a wide range of geographical terrains, ecotypes, and prevalence of malaria. It experiences a voluminous influx and efflux of people across the state that...

    Authors: Vani Hanumantappa Chalageri, Shrinivasa B. Marinaik, Sujith N. Nath, Richa Singhal, Smita Rawat, Krishnappa Ravikumar, Mahamood Shariff and Alex Eapen
    Citation: Malaria Journal 2023 22:353
    Content type: Research Published on:

  43. Malaria affects millions of Cameroonian children under 5 years of age living in the North and Far North regions. These regions bear the greatest burden, particularly for children under 5 years of age. To reduc...

    Authors: Arnold Fottsoh Fokam, Toussaint Rouamba, Sekou Samadoulougou, Yazoume Ye and Fati Kirakoya-Samadoulougou
    Citation: Malaria Journal 2023 22:347
    Content type: Research Published on:

  44. The efficacy of chloroquine treatment for vivax malaria has been rarely evaluated due to a lack of an appropriate testing method. The objective of this study was to conduct molecular monitoring of chloroquine ...

    Authors: Hongyun Ding, Ying Dong, Yan Deng, Yanchun Xu, Yan Liu, Jing Wu, Mengni Chen, Canglin Zhang, Li Liu and Yingkun Lin
    Citation: Malaria Journal 2023 22:338
    Content type: Research Published on:

  45. The Lao PDR National Strategic Plan for malaria control and elimination for year 2021–2025 emphasizes the importance of routine entomological surveillance being conducted in areas with high transmission and in...

    Authors: Sébastien Marcombe, Santi Maithaviphet, Rita Reyburn, Khamfong Kunlaya, Khambang Silavong, Bouasy Hongvanthong, Viengxay Vanisaveth, Viengphone Sengsavath, Vilasack Banouvong, Keobouphaphone Chindavongsa, Boualam Khamlome and Matthew Shortus
    Citation: Malaria Journal 2023 22:319
    Content type: Research Published on:

  46. Appropriate malaria treatment-seeking behaviour (TSB) is critical for timely detecting malaria, prompt treatment, and prevention of onward transmission of the disease in a community. This study aimed to compar...

    Authors: Jian-Wei Xu, Dao-Wei Deng, Chun Wei, Xing-Wu Zhou and Jian-Xiong Li
    Citation: Malaria Journal 2023 22:309
    Content type: Research Published on:

  47. Imperfect adherence is a major barrier to effective primaquine radical cure of Plasmodium vivax. This study investigated the effect of reduced adherence on the risk of P. vivax recurrence.

    Authors: Parinaz Mehdipour, Megha Rajasekhar, Saber Dini, Sophie Zaloumis, Tesfay Abreha, Ishag Adam, Ghulam Rahim Awab, J. Kevin Baird, Larissa W. Brasil, Cindy S. Chu, Liwang Cui, André Daher, Margarete do Socorro M Gomes, Lilia Gonzalez‑Ceron, Jimee Hwang, Harin Karunajeewa…
    Citation: Malaria Journal 2023 22:306
    Content type: Research Published on:

  48. Plasmodium vivax malaria is considered a major threat to malaria eradication. The radical cure for P. vivax malaria normally requires a 14-day administration of primaquine (PQ) to clear hypnozoites. However, main...

    Authors: Kyawt Mon Win, Pyae Linn Aung, Zau Ring, Nay Yi Yi Linn, Myat Phone Kyaw, Wang Nguitragool, Liwang Cui, Jetsumon Sattabongkot and Saranath Lawpoolsri
    Citation: Malaria Journal 2023 22:302
    Content type: Research Published on:

  49. Strengthening malaria control activities in Tanzania has dramatically declined human malaria infections. However, there is an increasing epidemiological shift in the burden on school-age children. The underlyi...

    Authors: Fadhila Kihwele, Tegemeo Gavana, Christina Makungu, Hajirani M. Msuya, Yeromin P. Mlacha, Nicodem James Govella, Prosper Pius Chaki and Bruno Fokas Sunguya
    Citation: Malaria Journal 2023 22:293
    Content type: Research Published on:

  50. Larval Source Management (LSM) is an important tool for malaria vector control and is recommended by WHO as a supplementary vector control measure. LSM has contributed in many successful attempts to eliminate ...

    Authors: Andy Hardy, Khamis Haji, Faiza Abbas, Juma Hassan, Abdullah Ali, Yussuf Yussuf, Jackie Cook, Laura Rosu, Arnon Houri-Yafin, Arbel Vigodny, Gregory Oakes, Silas Majambere and Eve Worrall
    Citation: Malaria Journal 2023 22:286
    Content type: Research Published on: