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Sex Differences in Autoimmune Disease

Edited by:

Kristine DeLeon-Pennell, PhD, Medical University of South Carolina, United States
Shannon Dunn, PD, PhD, Sunnybrook Research Institute and University of Toronto, Canada                                                                                                                     Professor DeLisa Fairweather, PhD, Mayo Clinic Florida, United States                                  Justin Van Beusecum, PhD, Medical University of South Carolina, United States

Submission Status: Open   |   Submission Deadline: 30 June 2025


Biology of Sex Differences is calling for submissions to our Collection on Sex Differences in Autoimmune Disease. Most autoimmune diseases occur predominantly in women. This Collection provides recent data and perspectives on Sex and Gender Differences in Autoimmune Diseases from leaders in the field.



Image credit: © Kateryna_Kon / stock.adobe.com

Meet the Guest Editors

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Kristine DeLeon-Pennell, PhD, Medical University of South Carolina, United States

Dr. Kristine DeLeon-Pennell is an Associate Professor in the Division of Cardiology at the Medical University of South Carolina (MUSC). She received her PhD in 2011 at Baylor University and was trained in cardiac physiology at the University of Texas Health Science Center San Antonio and the University of Mississippi Medical Center. Dr. DeLeon-Pennell’s research is focused on dissecting the interplay of pre-existing variables such as chronic inflammation, sex, and age on cardiovascular events. This includes dissecting the influence of the innate and adaptive immune system on cardiovascular remodeling, understanding the dynamics and function of bio-molecules involved in cardiac remodeling, and utilizing the knowledge acquired to develop therapeutic strategies to prevent, slow, or reverse the progression to heart failure.

Shannon Dunn, PD, PhD, Sunnybrook Research Institute and University of Toronto, Canada

Dr. Dunn is an Associate Professor of the Department of Immunology at the University of Toronto. She is also a scientist at Sunnybrook Research Institute and is the Canadian Institute of Health Research (CIHR) Sex and Gender chair in immunity.  She leads a research program that focuses on how risk factors for multiple sclerosis (MS) including female sex, obesity, and cigarette smoking impact the immune system to modulate the development and progression of central nervous system autoimmunity. She employs both animal models of MS and studies of human blood cells to investigate how these risk factors modulate the immune system. In her past work, she made important contributions to the understanding the role of female sex and obesity enhance autoimmunity by increasing T helper 1 inflammation.

Professor DeLisa Fairweather, PhD, Mayo Clinic Florida, United States

DeLisa Fairweather, PhD, is a Professor of Medicine at Mayo Clinic Florida with a joint appointment in the Department of Immunology. She is Vice-Chair of Translational Research for the Department of Cardiovascular Medicine and Co-Director of Research for the Ehlers-Danlos syndrome (EDS) Clinic at Mayo Clinic Florida. She has studied sex differences in autoimmune disease, with a focus on myocarditis, for 25 years. She served on the National Academies of Science, Engineering and Medicine (NASEM) committee to examine the NIH autoimmune disease portfolio which led to the formation of the Office of Autoimmune Disease Research in October 2023.

Justin Van Beusecum, PhD, Medical University of South Carolina, United States

Dr. Van Beusecum received his graduate school training in the Division of Nephrology at the University of Alabama at Birmingham. After completing his Ph.D., Justin pursued a postdoctoral fellowship at Vanderbilt University Medical Center in the Division of Clinical Pharmacology where he studied the role of immunity of vascular dysfunction in hypertension and cardiovascular disease. Dr. Van Beusecum was recruited to the Medical University of South Carolina in the Division of Nephrology. His research is focused on understanding the interaction and interplay between immune cells and endothelial cells in the genesis of autoimmunity and hypertension in a sex-dependent manner.

About the Collection

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Biology of Sex Differences invites authors to submit review articles, basic, clinical and/or translational research studies or theoretical articles to this Collection that aims to address recent data and perspectives on sex differences in autoimmune diseases (individual autoimmune diseases or collectively) on topics including but not limited to epidemiology, genetics, environmental factors (infections, chemicals, stress, etc.), immunology, mechanisms, biomarkers, and therapies. Please contact the Guest Editors of this Collection if you have any questions.

There are currently no articles in this collection.

Submission Guidelines

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This Collection welcomes submission of review articles, basic, clinical and/or translational research studies or theoretical articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. 

Articles for this Collection should be submitted via our submission system, Snapp. Please, select the appropriate Collection title “Sex Differences in Autoimmune Disease" under the “Details” tab during the submission stage.

Articles will undergo the journal’s standard peer-review process and are subject to all the journal’s standard policies. Articles will be added to the Collection as they are published.

The Editors have no competing interests with the submissions which they handle through the peer-review process. The peer-review of any submissions for which the Editors have competing interests is handled by another Editorial Board Member who has no competing interests.